Comparison of ibuprofen, cyclobenzaprine or both in patients with acute cervical strain: a randomized controlled trial

Consuming any medication together could be harmful for individual. Although this can lead to serious side effects like drowsiness and nausea. There is no interaction found between Flexeril and Ibuprofen together still you should always consult a doctor before consuming any medication.

Gabapentin for Arthritis: Uses, Dosage, Side Effects – Verywell Health

Gabapentin for Arthritis: Uses, Dosage, Side Effects.

Posted: Wed, 24 Aug 2022 07:00:00 GMT [source]

This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Data sources include IBM Watson Micromedex (updated 3 Sep 2023), Cerner Multum™ (updated 28 Aug 2023), ASHP (updated 10 Aug 2023) and others. For many people, short-term use of over-the-counter pain medications or nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, may provide temporary relief from jaw and muscle discomfort. The pharmacist performed a stratified randomization in blocks of 6 based on 2 sequences using a randomization plan generator.16 Patients were stratified based on results of the baseline RMDQ. The pharmacist masked the medication by placing cyclobenzaprine, oxycodone/acetaminophen, or placebo into identical unmarked capsules, which were then packed with small amounts of lactose and sealed.

Carisoprodol in acute back conditions: a double-blind randomized placebo-controlled study

The interaction also leads to other effects such as coma and respiratory distress. For example, Tizanidine when combined with Tramadol, can cause increased severity of CNS depression. If one experiences any one of the effects of this combination, the patient should seek medical attention immediately. If someone is trying to find out whether one can take these drugs and ibuprofen together, it is not recommended to mix both of them. If both are consumed in large doses, they may slow down breathing and leave the person sedated.

In fact, a trial by Cambridge University Press proved that there’s no point in adding cyclobenzaprine to ibuprofen, either. A review by NEJM Journal Watch confirms the same results; the NSAID works fine without the added help. For one, a randomized trial proved that cyclobenzaprine alone calms neck and back spasms just as well as a cyclobenzaprine-ibuprofen combination.

• Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
• If you experience any of these side effects, stop using the medication and contact your doctor.
• Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
• When combined, these drugs can increase the severity of CNS side effects.
• The symptoms of this syndrome include seizures, hallucinations, increased heart rate, fever, spasms, nausea, cramps, in-coordination, and diarrhea.

This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use. If you notice other effects not listed above, contact your doctor or pharmacist. Check your blood pressure regularly and tell your doctor if the results are high.

More About Drugs and Medications

Ibuprofen is commonly used for various conditions, including headaches, toothaches, menstrual cramps, and mild to moderate musculoskeletal pain. It is available over the counter and in prescription-strength forms, such as tablets or capsules. Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur.

Before taking ibuprofen, tell your doctor or pharmacist if you are allergic to it; or to aspirin or other NSAIDs (such as naproxen, celecoxib); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. When ibuprofen is used by children, the dose is based on the child’s weight.

Available data do not support the superiority of opioids over NSAIDs.19 In this study, oxycodone/acetaminophen + naproxen was not better than placebo + naproxen. We identified a difference in pain outcomes among participants who took oxycodone/acetaminophen more than once when compared with those who took placebo more than once. Furthermore, the magnitude of benefit was modest, with a number needed to treat of nearly 6 for moderate or severe pain, which is balanced by a number needed to harm of nearly 5.

In the US – Call your doctor for medical advice about side effects. You may report side effects to FDA at FDA-1088 or at /medwatch. If your doctor has prescribed this medication, remember that your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. If your condition lasts or gets worse, or if you think you may have a serious medical problem, get medical help right away.

Although it mimics the uses of muscle relaxers, one should also avoid valerian and muscle relaxant combination as it makes the patient sleepy and can lead to increased tiredness and drowsiness. Valerian can be used as an effective herbal muscle relaxer, but not in combination flexeril for shoulder pain with other pills. Novocaine is a medication that belongs to the drug class local anesthetics. Generally, doctors use this drug to numb a particular part of the body. The drug interactions between novocaine and muscle relaxers only show the effect at the neuromuscular junction.